For Nanotech Drug Delivery, Size Doesn't Matter Shape Does [News]
As nanotechnology to ferry drugs to their destinations is tested in both the laboratory and in clinical trials, scientists have made a surprising discovery about the kinds of nanoparticles that might be most effective for eventually transporting a number of different cancer-fighting therapies throughout the body.The conventional wisdom is that the smaller, the better. But that may not be true, according to a team of scientists led by University of North Carolina at Chapel Hill (U.N.C.) chemistry professor Joseph DeSimone. DeSimone and his colleagues have shown that the shape of these microscopic drug carriers is much more important than size and can even mean the difference between whether a drug penetrates target cells effectively or ends up as a target itself, only to be destroyed by the immune system. [More]