Small Peptides As Potential Antibiotics
Tuesday, March 25, 2014 - 11:10
in Health & Medicine
Drug approval requires a deep understanding of the mechanism of action The team of Julia Bandow, who heads the RUB's Junior Research Group Microbial Antibiotic Research, has been studying the MP196 peptide as a representative of a group of very small positively charged peptides that consist of some four to ten amino acids. Earlier studies had shown that MP196 is efficient against various bacteria, including particularly problematic multi-resistant pathogens that frequently cause sepsis. How MP196 kills bacteria remained unclear. However, in order for a new substance to be approved as a drug, its mechanism of action has to be fully understood. Peptide disrupts cell wall biosynthesis and cell respiration read more