“Promiscuous” protein interactions found in the nuclear pore complex

The NPC is the only way in or out of a cell’s nucleus. It plays a key role in cellular metabolism and signaling, and any malfunction in these pores can have lethal consequences. Now new research reveals further insights into the design of this evolutionarily ancient and little-understood transport machinery. The findings suggest that the nuclear pore complex takes on different formations to carry out its function.

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