Novel role of protein in generating amyloid-beta peptide

A defining hallmark of Alzheimer's disease is the accumulation of the amyloid beta protein (A-beta), otherwise known as 'senile plaques,' in the brain's cortex and hippocampus, where memory consolidation occurs. Researchers at the University of California, San Diego School of Medicine have identified a novel protein which, when over-expressed, leads to a dramatic increase in the generation of A-beta. Their findings, which indicate a potential new target to block the accumulation of amyloid plaque in the brain, will be published in the 1 May issue of the Journal of Biological Chemistry...

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