'Intrabody' Can Mop Up Mutant Protein In Huntington's Disease Model

Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Researchers engineered a virus to make an intracellular antibody or 'intrabody' against huntingtin, the protein whose mutant forms poison the brain cells of people with Huntington's. Injecting the virus into the brains of mice that make mutant huntingtin improves their ability to move their limbs, although it does not prolong their lives.

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