Human embryonic stem cells and reprogrammed cells virtually identical

Human embryonic stem cells and adult cells reprogrammed to an embryonic stem cell-like state -- so-called induced pluripotent stem or iPS cells -- exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state, according to researchers. Contrary to some recent research, the current findings rekindling hopes that, under the proper circumstances, iPS cells may hold the clinical promise ascribed to them earlier.

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