Earthquake potential where there is no earthquake history

It may seem unlikely that a large earthquake would take place hundreds of kilometers away from a tectonic plate boundary, in areas with low levels of strain on the crust from tectonic motion. But major earthquakes such as New Zealand's 2011 Mw 6.3 quake have shown that large earthquakes do occur. So what should seismologists look for if they want to identify where an earthquake might happen despite the absence of historical seismic activity?

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